Toxikon Corporation announces the availability of services for preclinical testing and development of ophthalmic drugs and devices.
Toxikon's in-house team, led by Dr. Kristine Erickson and Dr. Kathleen Krenzer, along with our distinguished consultants bring years of world class and award winning research in preclinical testing and development of ophthalmic drugs and devices. The research team is supported by the latest technologies, including laser doppler velocimetry for retinal blood flow measurements; scanning laser ophthalmoscopy, to determine retinal topography; fluorophotometer to measure aqueous humor flow; in vivo and in vitro organ culture anterior segment perfusion methodology; nuclear magnetic resonance spectroscopy; scanning and transmission electron microscopy, fluorescein angiography, fundus photography, corneal opacitometry for in vitro measurement of ocular irritation and state-of-the-art ocular surgery suite. Further, this expertise in Ophthalmology is supported by our multidisciplinary team at Toxikon to providing expertise in scientific and technical disciplines of pharmaceutics, analytical chemistry, microbiology, pharmacology, pharmacokinetics and drug metabolism, in vivo toxicology, reproductive toxicology, immunology, and genetic and molecular toxicology.
Our technical staff provides expertise in micro-dissection of ocular samples, surgical administration of ophthalmic drugs and devices including subconjunctival, sub-tenon, retrobulbar, periocular, intracameral, intravitreal, sub-retinal, intrascleral, and intrastromal administration. Our scientists are adept at the development and/or application of animal models needed to support preclinical safety and efficacy trials investigating ocular hypertension, glaucoma, ocular allergy, ocular inflammation, corneal irritation, ocular infection, corneal wound healing, retinal ischemia, diabetic retinopathy, retinitis pigmentosa, and macular degeneration. All this work is supported by Toxikon's extensive analytical capabilities to support ocular toxicokinetics, pharmacokinetics, bioavailability, and bioequivalence studies.
