Contact our Client Services Department for more information on these or other early stage/proof
of concept studies to support your R&D efforts.

Analytical

• Method development and validation
• HPLC, LC/MS, GC, GC/MS
• Bioanalytical LC/MS/MS
• ICP, ICP-MS, IR, UV/VIS
• Radio labeled analytical HPLC
• Adsorption studies
• Preclinical and clinical PK/BA/BE sample analysis
• Metabolite (known and unknown) profiling/radio profiling, identification and characterization

In Vitro Services

• Metabolism studies
• In Vitro intestinal permeability (CaCo2)
• Immunoglobulin assay
• In Vitro micronucleus
• Balb-C3T3 NRR phototoxicity assay
• Balb-C3T3 NRU cytotoxicity assay
• Embryotoxicity
• P450 isozyme mapping (phenotyping), induction and inhibition assays
• Mycoplasma detection by RT PCR method
• Ames screening assay
• Comet assay
• PCR
  

In Vivo Services/Devices
Selected capabilities:

• Visceral adhesion model
• Hernia repair model
• Placement of nerve stimulators
• Arthotomies
• Calvarial defects
• Cranial surgeries/brain implants
• Vascular implants/other
• Laser treatment studies in hairless mice

Pharma Services

• PK, TK and ADME
• Mass balance
• Tissue distribution
• Metabolite profiling/radio profiling and identification
• Discovery PK
• Formulation bioavailability screening
• Toxicokinetic
• Cassette PK
• Drug-drug interaction

Disease modules available:

• Gastric ulcer model in rats
• Inflammatory Bowel Disease (IBD) model in rats and mice
• Rheumatic arthritis models (collagen induced) in rats and mice
• Lung inflammation in mice
• Conjunctival scarring models
• Trabeculectomy model
• Retinopathy of prematurity in mice
• Allergic conjunctivitis models
• Intravitreal models
• Ocular and retinal testing (ERG) and development studies
• Immunotoxicity
• Other efficacy models