Bioanalysis

Toxikon Corporation provides extensive bioanalytical testing services, which are required for determination of compounds using validated and quantitative methods. Samples (drug or metabolite concentrations) can be derived from various biological matrices such as plasma, serum, urine, etc. using latest analytical instruments.

Toxikon's scientists can assist you in fulfilling requirements in compliance with the appropriate guidelines of FDA and other international agencies.

Services include:

• Method development and validation for biological samples and preclinical dose formulations
• Analysis of biological samples from PK/TK, ADME studies, and human clinical trials
• Characterization of test articles consisting of purity determinations, identity confirmation, and identification and quantification of impurities (LC/MS/MS, GC/MS) and metabolites
• Stability determination of test articles and preclinical dose formulations
• Routine analysis of preclinical dose formulations for homogeneity and concentration
• Metabolite isolation and determination

A partial list of equipments include API® 4000™ Triple Quadruple MS with Shimadzu HPLC, LEAP HTC Autosampler, LEAP HTS PAL Autosampler, Agilent 1100 LC, Agilent 1100 MSD, etc.