Ocular Studies

Ocular Testing

Ocular studies include acute irritation, ocular distribution (pharmacokinetics and pharmacodynamics – PK/PD), acute and repeat dose toxicity, implantation, drug screening and drug efficacy.  We can also customize studies for targeted therapeutics, such as:

  • dry eye
  • corneal wound healing
  • inflammation
  • uveitis
  • neovascularization
  • age-related macular degeneration
  • glaucoma
  • neuroprotection

As part of our extensive custom research and testing portfolio for ophthalmic drug discovery, we offer a variety of preclinical services, including the screening of neuroprotective compounds and creation of animal models for glaucoma research.

 

Ophthalmic Development Capabilities

  • Intra-vitreal injections
  • Stereotaxic surgery
  • Aesthesiometry, tonometry, pupilometry; and electroretinography (ERG)
  • Slit-Lamp exams and Draize and McDonald-Shadduck scoring systems using direct and indirect ophthalmoscopy
  • Anterior/posterior segment and fundus photography
  • Ocular tissue dissection, distribution and PK/PD/Absorption, distribution, metabolism, excretion (ADME)
  • Retina/choroid flat-whole mounting, confocal microscopy, and retinal ganglion cell quantitation
  • Ocular histology/pathology and clinical support
  • Stereo and fluorescent microscopy
  • Optic nerve damage assessment
  • Specialized surgeries (e.g. episcleral vein injections to induce elevated intraocular pressure (IOP))

Toxikon is focused on evaluating the safety and toxicity of biologics, pharmaceuticals and medical devices. Our experienced study directors will provide you with the expertise in ophthalmology models and endpoints for your ocular drug program

 

Toxikon Ocular Techniques & Capabilities

Ocular Examinations

  • Anterior segment of the eye
  • Slit-Lamp; Draize and McDonald-Shadduck scoring systems
  • Posterior segment of eye
  • Direct & indirect ophthalmoscopy

Corneal Sensitivity Measurements

  • LUNEAU Cochet-Bonnet Aesthesiometry

Pupillary Response Assessment

  • NEUROPTICS Pupillometry PLR-100

Retinal Function

  • Espion E2 system full-field electroretinography (ERG)
  • Pattern electroretinography (pERG)

Photography and Videography

  • Anterior/posterior segment and fundus
  • Topcon imaging systems
  • Carl Zeiss capture HD (1080P) video & movie systems

Laser Photocoagulation

Fluorescein Angiography

Intraocular Pressure Measurements

  • Tonometry (TonoPen, TonoVet, LabVet)

Complete Eye Tissue Dissection

  • Dissection microscopy
  • Retinal/Choroidal Flat Wholemounts

Microsurgery

  • Surgical microscopy
  • Stereotaxic surgery

Histopathology

  • Routine H&E staining, Immunohistochemistry
  • Other special staining
  • Immunology

 

Support Services for Ocular Programs

  • Ocular Drug Research and Development
  • Surgical and Efficacy
  • Formulation Lab
  • IND/NDA Enabling Studies
  • Pathology
  • Ocular PK/Tissue Distribution

 

Ocular PK/Tissue Distribution

The purpose of this study is to evaluate the ocular distribution of the test article and a predicate control in the ocular tissues when administered topically to the surface of the eye. 

 

Toxikon Expertise in Ocular Studies

Our extensive custom research and testing portfolio for ophthalmic drug discovery, we offer a variety of preclinical services, including the screening of neuroprotective compounds and creation of animal models for glaucoma research. We can also customize studies for targeted therapeutics, such as dry eye and corneal wound healing, inflammation and uveitis, neovascularization and age-related macular degeneration, glaucoma and neuroprotection.

 

Ocular Studies
Ocular, Ocular Studies, pharmacokinetics and pharmacodynamics, PK/PD, Ophthalmic Development, Corneal Sensitivity Measurements, Pupillary Response Assessment, Uvetis, neovascularization, dry eye, inflammation, corneal wound healing, glaucoma, retinal,
Ocular studies include acute irritation, ocular distribution (pharmacokinetics and pharmacodynamics – PK/PD), acute and repeat dose toxicity, implantation, drug screening and drug efficacy. Contact Toxikon today for Ocular studies offerings.